Most drugs however, are not tested in pregnant women to avoid the potential harm to the mother and fetus. Additionally, if a drug is considered safe to take early in the first trimester, it may turn out to be harmful during the last few months of pregnancy as the body's physiology changes throughout pregnancy. Still, there are some drugs that initially had an unclear safety rating but later received a safe rating after many women taking the drug during pregnancy had no ill effects.
So the FDA has created a system that assigns a safety category-A, B, C, D and X-which must be applied to the labels of all drugs. While this may look like a bad game of Scrabble, these letters represent very important information about drug safety during pregnancy. Since 1996, every drug label includes a statement about the drug's known effects on pregnancy.
This system, which has been criticized for its vague definitions and use of medical jargon, can be difficult to interpret. But an understanding of how these categories are assigned can help pregnant women make very important decisions.
FDA Pregnancy Category Chart
This chart resembles a tier, with the safest drugs falling under the category A, the least-safe drugs at the bottom in the category X.
